The 2022 International Conference on Computing and Data Science (CONF-CDS 2022) was held from July 16 to 25, 2022. The accepted papers will be published in conference proceedings and submitted to EI Compendex, Conference Proceedings Citation Index (CPCI), Crossref, CNKI, Portico, Inspec, Scopus, Google Scholar, and other databases for indexing. Prof. Chengzhong Xu from University of Macau, Prof. Tanzila Saba from Prince Sultan University, Prof. Li Xiong from Emory University, and Prof. Lewis Tseng from Boston College, Massachusetts have given keynote speeches on related topics of machine learning, big data management, state-machine replication, and autonomous driving. Also, we invited authors of qualified papers to deliver oral presentations at the online conference. 15 authors have presented their studies of image data visualization, machine learning, convolutional neural network, and ICP algorithm. Questions from the audience were collected and answered by the presenters. This conference provided the participants with good opportunities to exchange ideas and build networks, and it will lead to further collaborations between both universities and other societies.